许多发生于成年人的非霍金氏淋巴瘤是大细胞淋巴瘤，如图中倍镜示。可能与免疫抑制状态有关（例如AIDS），是典型B细胞起源的肿瘤。细胞体积大，有明显的核和丰富的细胞质。早期趋向于局部化，但随后迅速扩大，比较低级的淋巴瘤有更大的侵袭淋巴结外组织的倾向。
Many non-Hodgkin's lymphomas seen in adults are large cell lymphomas such as the one here at medium power, but they can be associated with immunosuppressed states (such as AIDS), and are typically of B cell origin. The cells are large, with prominent nucleoli and abundant cytoplasm. This disease tends to be localized (low stage), but with more rapid enlargement, and a greater propensity to be extranodal than the low grade lymphomas.
