Graves病典型的病变是甲状腺弥漫性对称性肿大，当然伴有甲状腺功能亢进。低倍镜下，滤泡上皮呈乳头状增生。在这类自身免疫病中，甲状腺刺激免疫球蛋白（TSI）的作用远强于甲状腺生长刺激免疫球蛋白（TGI）的作用。

Graves病：显微镜一　二

A diffusely enlarged thyroid gland associated with hyperthyroidism is known as Grave's disease. At low power here, note the prominent infoldings of the hyperplastic epithelium. In this autoimmune disease the action of TSI's predominates over that of TGI's.